xxxv Summary of Major Changes in the 2021 Red Book MAJOR CHANGES: GENERAL 1. All chapters in the last edition of the Red Book were assessed for relevance in the dynamic environment that is the practice of pediatric medicine today. The School Health chapter was noted to have significant overlap with the Children in Out-of- Home Child Care chapter, so they were merged in the 2021 edition into a single chapter titled Children in Group Child Care and Schools. In addition, the Vaccine Injury Table appendix was deleted. Two chapters have been added to the 2021 edition: Pseudomonas aeruginosa Infections and a new Systems- based Treatment Table that is designed to aid in initial antibiotic selections by clinical condition, before the specific pathogen is known. 2. The 2018 Red Book had 9% fewer chapters compared with the 2015 edition, and yet the total book was 60 pages longer. As we started work on the 2021 Red Book, we therefore identified the 31 chapters that were 10 pages or longer in the 2018 edition, and made a targeted effort to trim them so that all relevant information could more easily and quickly be located. Although some of these 31 chapters (eg, the antibiotic or antiparasitic tables) could not be truncated, we overall achieved our goal by decreasing the 2021 Red Book by 41 pages compared with the 2018 edition. 3. Every chapter in the 2021 Red Book has been modified since the last edition. The list- ing below outlines the more major changes throughout the 2021 edition. 4. To ensure that the information presented in the Red Book is based on the most accu- rate and up-to-date scientific data, the primary reviewers of each Red Book chapter were selected for their specific academic expertise in each particular area. In this edition of the Red Book, 32% of the primary reviewers were new for their assigned chapters. This ensures that the Red Book content is viewed with fresh eyes with each publication cycle. 5. Throughout the Red Book, the number of websites where additional current and future information can be obtained has been updated. All websites are in bold type for ease of reference, and all have been verified for accuracy and accessibility. 6. Reference to evidence-based policy recommendations from the American Academy of Pediatrics (AAP), the Advisory Committee on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention (CDC), and other select professional organizations have been updated throughout the Red Book. 7. Standardized approaches to disease prevention through immunizations, antimicro- bial prophylaxis, and infection-control practices have been updated throughout the Red Book. 8. Policy updates released after publication of this edition of the Red Book will be posted on Red Book Online. Red_Book_2020_FM.indd 35 30/03/21 11:58 AM
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