APPENDIX III— NATIONALLY NOTIFIABLE INFECTIOUS DISEASES 1033 IN THE UNITED STATES­­ Appendix III Nationally Notifiable Infectious Diseases in the United States Nationally notifiable infectious diseases are those that public health officials from local, state, and territorial public health departments voluntarily report to the Centers for Disease Control and Prevention (CDC). Surveillance for nationally notifiable infectious diseases helps public health agencies monitor the occurrence and spread of disease across the nation and evaluate prevention and control measures, among other pur- poses. To ensure consistency in how the data are classified and enumerated, national surveillance case definitions are established and used for each disease. The Council of State and Territorial Epidemiologists (CSTE), with advice from the CDC, reviews the list of nationally notifiable infectious diseases on an annual basis and may rec- ommend that a disease be added or deleted from the list or that a case definition be revised. Provisional nationally notifiable infectious disease data are published in weekly tables and finalized data are published in annual tables, available from the “Data and Statistics” section of the National Notifiable Diseases Surveillance System website ( Data on approximately 120 nationally notifiable diseases, most of which are infectious diseases, are reported to the CDC from all states, Washington DC, New York City, and five US territories on either a daily or weekly basis. A subset of cases that meet the criteria for being a potential public health emergency of international concern, as per the 2015 revised International Health Regulations (, are notified by the CDC’s Emergency Operations Center to the Department of Health and Human Services Secretaries Operations Center, which in turn notifies the World Health Organization. The World Health Organization makes the final determination about whether a public health emergency of international concern exists. The 2019 list of nationally notifiable infectious diseases is included in Table 1. Should a more current list of such diseases be needed, visit Nationally notifiable infectious disease reports are based on data collected at the local, state, and territorial levels as a result of legislation and regulations in those juris- dictions that require health care providers, clinical laboratories, hospitals, and other entities to submit health-related data on reportable diseases to public health depart- ments. Case reporting to local, state, or territorial public health officials provides them the information needed to investigate these diseases and to implement prevention and control strategies, among other purposes. Because the list of reportable infectious dis- eases is determined by local, state, and territorial law and varies by jurisdiction, health care providers, clinical laboratories, hospitals, and other required reporters are strongly encouraged to obtain specific reporting requirements from the appropriate public health department, including the timeliness required for case reporting. If a reportable disease meets the criteria for a nationally notifiable infectious disease, the local, state, or territorial public health department will submit a case noti- fication to the CDC. The timeliness of such case notifications to the CDC varies by disease, with some requiring notification within 4 hours of a case meeting the notifica- tion criteria. Red_Book_2020_APPENDIX_1027-1060.indd 1033 19/02/21 10:05 AM
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