XXXVI SUMMARY OF MAJOR CHANGES IN THE 2018 RED BOOK 10. Policy updates released after publication of this edition of the Red Book will be posted on Red Book Online. 11. Appropriate chapters throughout the Red Book have been updated to be consistent with 2018 AAP and CDC vaccine recommendations, CDC recommendations for immunization of health care personnel, and drug recommendations from 2018 Nelson’s Pediatric Antimicrobial Therapy.1 12. Several tables and figures have been added for ease of information retrieval. SECTION 1. ACTIVE AND PASSIVE IMMUNIZATION 1. Information sources about immunization have been updated and added. A resource for the names of international vaccines also has been added, as has a quick reference table for Web site addresses for reliable information on immunization. 2. Information from the 2016 AAP clinical report “Countering Vaccine Hesitancy” has been incorporated in the Discussing Vaccines With Patients and Parents chapter. 3. New vaccines approved since 2015 have been added to the Active Immunization chapter, and those removed from the market have been deleted. 4. New information on pharmacologic options, including over-the-counter topical medications, for Managing Injection Site Pain has been added. 5. Guidance on timing of administration of Menactra (MCV4-D, Sanofi Pasteur) and Daptacel (DTaP, Sanofi Pasteur) in children 4 through 6 years of age has been added to the Timing of Vaccines and the Immunization Schedule chapter, based on recent data indicating that administration of Menactra 1 month after Daptacel reduces meningococcal antibody response to Menactra. 6. The epidemiology of increased risk of seizure among recipients of concurrent influenza vaccine and conjugate pneumococcal vaccine has been updated in the chapter on Simultaneous Administration of Multiple Vaccines. 7. HibMenCY has been removed from the Combination Vaccines chapter following its removal from the US market. 8. The Unknown or Uncertain Immunization Status chapter now includes recent guidance on reconciling documentation of adequate poliovirus vaccination in refugee or immigrant children immunized internationally. 9. Oral typhoid vaccine has been added to the chapter on Active Immunization of People Who Recently Received Immune Globulin and Other Blood Products. The table detailing the suggested intervals between IG administration and active immunization with MMR, MMRV, or monovalent varicella vaccines has been updated to account for a new BabyBIG formulation, recent changes to the measles IG prophylaxis recommendations, and inclusion of the time interval following CMV hyperimmune globulin. 10. The Vaccine Adverse Event Reporting System chapter has updated information on monitoring of VAERS reports and reporting of adverse events. 11. Information on 21st Century Cures and on pregnant women has been added to the Vaccine Injury Compensation chapter. 1Bradley JS, Nelson JD, Barnett ED, et al, eds. 2018 Nelson’s Pediatric Antimicrobial Therapy. 24th ed. Elk Grove Village, IL: American Academy of Pediatrics 2018
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