vii Introduction We are now in our 25th edition of Nelson’s Pediatric Antimicrobial Therapy, a tribute to John Nelson’s belief that advice on treatment of children with infections should be clear and concise! Although no new oral anti-infective agents have been approved in the United States recently, several antibiotics in many classes that completed adult studies are now entering pediatric clinical trials, particularly those for multidrug-resistant Gram-negative bacilli. The contributing editors, all very active in clinical work, have updates in their sections with relevant new recommendations based on current pub- lished data, guidelines, and clinical experience. We hope that the reference list for each chapter provides the available evidence to support our recommendations, for those who wish to see the data. For those who use the Nelson’s app, you may have noticed a new “feel” to the app, which is now written in one of the Apple programing languages by Dr Howard Smart, a full- time office-based pediatrician and the chief of pediatrics at the Sharp Rees-Stealy multi- specialty medical group in San Diego, CA. With the support of the American Academy of Pediatrics (AAP) (particularly Peter Lynch) and the editors, we are putting more of Howard’s enhancements in this 2019 edition. So substantial are his contributions to the app, the book (from the perspective of an office-based pediatrician), and the develop- ment of future Nelson’s digital versions that the editors and the AAP have unanimously asked Howard to join us officially as a contributing editor. We believe that his skills (clinical and digital) are an essential part of what we all hope the AAP Nelson’s book can and should be. Recognizing the talent in collaborators/colleagues of the editors and their substantial and ongoing contributions to the quality of the material that is presented in this book, we wish to continue to acknowledge their advice each year in this Introduction. We con­ tinue to receive valuable suggestions from Drs John van den Anker and Pablo Sanchez on antimicrobial therapy of the newborn, in support of the work done by JB Cantey and Jason Sauberan in Chapter 5. A pediatric hospital medicine consulting editor who is with us again this year is Dr Brian Williams, a pediatric/adult hospitalist who trained with us at the University of California, San Diego, School of Medicine/Rady Children’s Hospital San Diego and is now in Madison, WI. His continuing advice on organizing information for both the book and the app has been invaluable. He is focused, practical, and very collaborative. We continue to harmonize the Nelson’s book with Red Book: 2018–2021 Report of the Committee on Infectious Diseases, 31st Edition (easy to understand, given that Dr David Kimberlin is also the editor of the Red Book). We are virtually always in sync but often with additional explanations (that do not necessarily represent AAP policy) to allow the reader to understand the basis for recommendations. ch00-Nelson-2019_FM_i-xii.indd 7 11/12/18 2:51 PM
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