Strength of Recommendation Description
A Strongly recommended
B Recommended as a good choice
C One option for therapy that is adequate, perhaps amon
many other adequate therapies
Level of Evidence Description
I Based on well-designed, prospective, randomized,
and controlled studies in an appropriate population
of children
II Based on data derived from prospectively collected,
small comparative trials, or noncomparative
prospective trials, or reasonable retrospective data
from clinical trials in children, or data from other
populations (eg, adults)
III Based on case reports, case series, consensus
statements, or expert opinion for situations in
which sound data do not exist
As we state each year, many of the recommendations by the editors for specific situa-
tions have not been systematically evaluated in controlled, prospective, comparative
clinical trials. Many of the recommendations may be supported by published data, bu
the data may never have been presented to or reviewed by the US Food and Drug
Administration (FDA) and, therefore, are not in the package label. We in pediatrics fi
ourselves in this situation frequently. Many of us are working closely with the FDA to
try to narrow the gap in our knowledge of antimicrobial agents between adults and ch
dren; the FDA is providing an exceptional effort to shed light on the doses that are saf
and effective for neonates, infants, and children.
We are all deeply grateful for the hard work and tireless efforts of our AAP colleagues
Alain Park, our senior product development editor for many years, has decided to tak
his interest in teaching to the next level, and we will miss his kind and steady input fo
future directions of our book. However, we have just met Barrett Winston, who, alon
with Peter Lynch (who has been working on developing Nelson’s online), will togethe
be our primary AAP contacts for the specifics of development and production of the
book. Barrett has considerable experience in medical publications, and we believe her
input, along with Peter’s, will be critical to ensuring the success and accuracy of our
book. We continue to appreciate the teamwork of all those at AAP who make sure thi
book gets to all the clinicians who may benefit. Thanks to Mark Grimes, Director,
Department of Publishing, and our steadfast friends and supporters in the AAP depar
ments of Publishing and Marketing and Sales—Jeff Mahony, Director, Division of
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