Introduction
Welcome to the 22nd edition of the book John Nelson started in 1975 to help clini-
cians select the most appropriate therapy for children with infections! Our collabora
tion with the American Academy of Pediatrics (AAP) continues to be very producti
as we learn more about how our book can address infectious diseases in childhood,
the antimicrobials available to treat them, and how clinicians access accurate and re
vant information as they care for children. We have had positive feedback from clin
cians into why we select a particular drug at a particular dose. We are very pleased
that many providers appreciate the references that we share in the print and app ver
sions so that they can get all the relevant facts that go into our recommendations for
therapy.
John Leake, our international health expert and the author of our chapter on parasit
infections for several years, now spends his time in laboratory medicine, developing
tests for new and important diseases (like Ebola). However, we are extremely fortun
that Elizabeth Barnett, an expert in international/traveler health from the Boston
University School of Medicine, is now joining us and, over the next editions, will giv
the chapter more of a focus on travel, immigrant, and refugee international health
issues. She is the site director of the GeoSentinel Surveillance Network, created by th
International Society of Travel Medicine and the US Centers for Disease Control an
Prevention. She was recently appointed to the prestigious Red Book® Committee on
Infectious Diseases of the AAP.
Jason Sauberan continues to carefully update the antimicrobial drugs and dosages fo
all children (Chapter 11), with particular attention to children with obesity (Chapter
12) and neonates (Chapter 5), which he writes with JB Cantey (under the watchful e
of Pablo Sanchez) and John van den Anker, a neonatologist/pharmacologist from
Children’s National Medical Center, who has again generously agreed to review our
neonatal antibiotic chapter. Neonatal pharmacology of antimicrobials continues to b
an area of intense study.
All of our editors have substantial clinical weeks “on service,” which clearly shows in
the insights provided by the antimicrobial recommendations, particularly for difficu
infections. They are some of the best clinicians in the field of pediatric infectious dis
eases, all with academic interests in performing investigations to find out which new
as well as older agents work best to treat infections. They take the time to partner w
the AAP and provide amazing advice in their particular areas of interest, knowledge
and experience.
The advice, experience, and knowledge of published/unpublished data are provided
with a grading of our recommendations: our assessment of how strongly we feel abo
a recommendation and the strength of the evidence to support our recommendatio
(noted on the next page).
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