in the 2015 Red Book
MAJOR CHANGES: GENERAL
1. To ensure that the information presented in the Red Book is based on the most accu-
rate and up-to-date scientific data, the primary reviewers of each Red Book chapter
were selected for their specific academic expertise in each particular area. In this
edition of the Red Book, 62% of the primary reviewers were new for their assigned
chapters. This ensures that the Red Book content is viewed with fresh eyes with each
2. Every chapter of the Red Book has been modified since the 2012 edition. The listing
below outlines the more major changes throughout the 2015 edition.
3. All Diagnostic Tests portions of the pathogen-specific chapters in Section 3 were
reviewed by a single microbiology laboratory director to ensure that they include the
state-of-the-art diagnostic modalities.
4. Throughout the Red Book, the number of Web sites where additional current and
future information can be obtained has been updated. All Web sites are in bold type
for ease of reference, and all have been verified for accuracy and accessibility.
5. Reference to evidence-based policy recommendations from the American Academy
of Pediatrics (AAP), the Advisory Committee on Immunization Practices (ACIP) of
the Centers for Disease Control and Prevention (CDC), and other select professional
organizations have been updated throughout the Red Book.
6. Standardized approaches to disease prevention through immunizations, antimicrobial
prophylaxis, and infection-control practices have been updated throughout the Red Book.
7. Wording regarding doxycycline has been harmonized throughout the Red Book.
Tetracycline-based antimicrobial agents, including doxycycline, may cause perma-
nent tooth discoloration for children younger than 8 years if used for repeated treat-
ment courses. However, doxycycline binds less readily to calcium compared with
older tetracyclines, and in some studies, doxycycline was not associated with visible
teeth staining in younger children (see Tetracyclines, p 873).
8. Policy updates released after publication of this edition of the Red Book will be posted
on Red Book Online.
9. Appropriate chapters throughout the Red Book have been updated to be consistent
with AAP and CDC 2015 vaccine recommendations, CDC sexually transmitted dis-
ease guidelines, CDC recommendations for immunization of health care personnel,
and drug recommendations from 2015 Nelson’s Pediatric Antimicrobial Therapy. (Bradley
JS, Nelson JD, Cantey JB, Kimberlin DW, Leake JAD, Palumbo PE, Sauberan J,
Steinbach WJ, eds. 21st ed. Elk Grove Village, IL: American Academy of Pediatrics;
2015), as well as recommendations for treatment and prevention of opportunistic
infections among children infected with or exposed to human immunodeficiency
virus (HIV) from the CDC, National Institutes of Health, and Infectious Diseases
Society of America.