Appendix IV
Nationally Notifiable Infectious Diseases in the United States
Nationally notifiable infectious diseases are those that public health officials from state and
territorial public health departments voluntarily report to the Centers for Disease Control
and Prevention (CDC). Notifiable disease data are based on data collected at the state, ter-
ritorial, and local levels as a result of legislation and regulations in those jurisdictions that
require health care providers, medical laboratories, and other entities to submit health-
related data on reportable conditions to public health departments. Notifiable disease sur-
veillance helps federal, state, and local public health monitor the occurrence and spread of
disease across the nation and to evaluate prevention and control measures, among other
purposes. To ensure consistency, national public health surveillance case definitions are
established and used for each disease. The Council of State and Territorial Epidemiologists
(CSTE), with advice from the CDC, reviews the list of nationally notifiable infectious dis-
eases on an annual basis and may recommend that a disease be added or deleted from the
list or that a case definition be revised. The current list is included in Table 1. Provisional
data are published weekly and finalized data are published annually in the Morbidity and
Mortality Weekly Report and the Summary of Notifiable Diseases, United States, respectively.
Because the list of reportable diseases and conditions is determined by state or territo-
rial law and varies by jurisdiction, health care providers are strongly encouraged to obtain
specific reporting requirements from the appropriate local, state, or territorial public
health department, including the timeliness required for case reporting. Case reporting to
local, state or territorial public health officials provides them the information needed to
investigate these diseases or conditions and to implement prevention and control strate-
gies, among other purposes.
If a reportable disease or condition meets the criteria for a nationally notifiable condi-
tion, the state or territorial health department will submit a case notification to the CDC.
The timeliness of case notifications sent to CDC from the state or territory CDC varies
by condition, and notifications are summarized on the CDC National Notifiable Diseases
Surveillance System Web site (wwwn.cdc.gov/nndss/document/NNC_2015_
Notification_Requirements_By_Category.pdf).
Notifications are categorized as:
1. Immediate, extremely urgent: The state/territorial health department must
notify the CDC by phone within 4 hours of a case meeting the notification criteria,
followed by submission of an electronic case notification to CDC by the next business
day (eg, paralytic poliomyelitis; SARS-associated coronavirus; smallpox; anthrax attrib-
utable to an intentional release, unrecognized source, or naturally occurring source
resulting in serious illness).
2. Immediate, urgent: The state/territorial health department must notify the CDC
by phone within 24 hours of a case meeting the notification criteria, followed by sub-
mission of an electronic case notification in the next regularly scheduled electronic
transmission (eg, measles, rubella, diphtheria, yellow fever, novel influenza A virus
infection, brucellosis, naturally occurring anthrax).
3. Standard: The state/territorial health department must submit electronic case notifi-
cation within the next reporting cycle (eg, mumps, pertussis, tuberculosis, shigellosis).
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