Introduction
Welcome to the 23rd edition of Nelson’s Pediatric Antimicrobial Therapy, now 42 yea
since the first edition was created by John Nelson and shipped from his garage from h
home in Dallas, TX. He had decided to put down his thoughts in a small pocketbook
help clinicians select the most appropriate therapy for children with infections! The
book has grown extensively since the first edition, and the printed version does not so
easily fit in one’s pocket. We continue our close and productive collaboration with the
American Academy of Pediatrics (AAP) to address the important infectious diseases i
childhood and the antimicrobials available to treat them. We hope to provide clinicia
with accurate, relevant, practical, and easily accessed information as they care for chil-
dren. We are very pleased that many providers appreciate the references that we share
the print and app versions so they can get the important facts that go into our recom-
mendations for therapy. The references are designed to share important studies and
reviews so clinicians may take our suggestions and use them to help treat children wit
unusual infections or unusual presentations of common infections.
Jason Sauberan continues to carefully update the antimicrobial drugs and dosages for
all children, an increasing challenge (Chapter 11), with particular attention to children
with obesity (Chapter 12) and neonates (Chapter 5), which he writes with JB Cantey
(under the watchful eye of Pablo Sanchez) and John van den Anker, a neonatologist/­
pharmacologist from Children’s National Medical Center, Washington, DC, who has
again generously agreed to review our neonatal antibiotic chapter. Neonatal pharmac
ogy of antimicrobials continues to be an area of intense study. We help with the writi
of the AAP Red Book (an official policy of the AAP, approved by its Board of Director
Although the Nelson’s book is not official policy, the doses and drugs recommended
should be very similar between the two.
All of our editors have substantial clinical weeks “on service,” which clearly shows in t
insights provided by the antimicrobial recommendations, particularly for difficult infe
tions. They are some of the best clinicians in the field of pediatric infectious diseases,
having academic interests in performing investigations to find out which newer as we
as older agents work best to treat infections. They take the time, working with the AA
to provide advice and insight into their particular areas of interest, knowledge, and ex
rience. The “Comments” columns in this book’s tables are designed to provide a per-
sonal discussion on some interesting or controversial areas that may be very importan
for managing children.
The advice, experience, and knowledge of published/unpublished data are provided w
a grading of our recommendations: our assessment of how strongly we feel about a re
ommendation and the strength of the evidence to support our recommendation (note
on the next page).
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